Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity.

PLoS One · 2025 · PMC12747322 · PMID 41460788

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a decreasing trendno p-value reported

CYP2D6 expression in differentiated transgenic cell lines remained significantly higher than that in WT cells, while CYP1A2 expression showed a decreasing trend ( S6 Fig ).

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did not reach statistical significanceno p-value reported

Meanwhile, cell viability exhibited an upward trend in #3 FLAG-CYP2D6 cells relative to WT controls, though this increase did not reach statistical significance.

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