Identification of Cathepsin H and Metabolic Traits as Potential Biomarkers for Lung Cancer by Mendelian Randomization and Single-Cell Transcriptomics.

APC or AAPC greater than 0 indicated an increasing trend in lung cancer during that period, whereas values less than 0 indicated a decreasing trend.

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Both in the overall myeloid cell data (Figure 6H ) and in the selected two cell types (Figure 6I ), we observed a clear trend of “Alveolar Mac” evolving toward “mo‐Mac.” This was consistent with the general direction of tumor development.

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