Barely Significant
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Psychiatric Risk Factors for Progression From Mild Cognitive Impairment to Alzheimer's Disease: A Systematic Review.

Am J Geriatr Psychiatry Open Sci Educ Pract · 2025 · PMC12747564 · PMID 41472721

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Whereas they reported higher risk of dementia in those taking antidepressants without a diagnosis of depression this finding did not reach statistical significance despite a very large sample size (446,267 total participants; 25,785 diagnosed with dementia), calling into question whether the risk associated with antidepressants was due to antidepressants or underlying depression/psychopathology.

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