Schwann cell Lrp1 deletion drives trigeminal neuron sensitization and orofacial pain by modulating mitochondrial function and TRPV1/TRPA1 activity.

This reduction was more pronounced in females, while males showed a nonsignificant trend toward reduction (Fig. 1 c).

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When analyzed by sex, male scLrp1 -/- mice displayed a significant increase in mechanical sensitivity whereas females showed a similar trend that did not reach statistical significance (Fig. 1 a).

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