Whereas hyperoxia-placebo exposed rat pups had increased aortic fibrosis, as evidenced by Masson’s Trichrome staining of the aorta, treatment with caspase-1 inhibitor showed a trend to decrease fibrosis.
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Caspase-1 inhibition mitigates neonatal hyperoxia-induced vascular and cardiopulmonary inflammation in neonatal rats.
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