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Efficacy of antioxidant supplementation in alleviating endometriosis-related pain: insights from a systematic review and meta-analysis of RCTs.

Reprod Biol Endocrinol · 2025 · PMC12751427 · PMID 41462252

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Among other antioxidants examined, vitamin E showed limited efficacy as monotherapy [ 9 ], though its combination with vitamin C [ 8 , 18 , 25 ] demonstrated marginal benefits that did not reach statistical significance in our analysis.

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borderline significantno p-value reported
The borderline significant test for subgroup differences suggests intervention duration may partly explain variability in antioxidant efficacy for dysmenorrhea (Table 2 ).

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