Tumor-Informed ctDNA in Guiding First-Line Immunochemotherapy in Advanced Non-Small Cell Lung Cancers.

Adv Sci (Weinh) · 2025 · PMC12752622 · PMID 41287887

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The interaction between therapeutic regimens (ICI‐chemo vs chemotherapy) and tumor‐informed ctDNA status showed significance for PFS, but the difference did not reach statistical significance for OS (p interaction = 0.026 for PFS, p interaction = 0.105 for OS, Figure 2A–D ), suggesting a specific predictive role of tumor‐informed ctDNA status for superior PFS of ICI‐chemo over chemotherapy alone.

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