Purine Nucleoside Phosphorylase Inhibition Rebalances Purine Metabolism and Attenuates Organ Damage in Sickle Cell Mice.

Levels of both plasma AST and urinary haemoglobin in the SS mice treated for 8 and 20 weeks were lower than in untreated SS mice (Figure 4K,L ), however, the results did not reach statistical significance.

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