A novel chimeric coronavirus spike vaccine combining SARS-CoV-2 RBD and scaffold domains from HKU-1 elicits potent neutralising antibody responses.

Anti-RBD WT IgG titres appeared higher in three of the five CTR-WT animals compared to the spike WT group (median: 2.12 × 10 4 vs 8.01 × 10 3 , respectively), although there was substantial variability across the modest numbers of outbred macaques and this did not reach statistical significance.

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