Expanding the role of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: A multicenter study on uncommon peritoneal malignancies.

The risk of major complications was more than twofold higher in group B compared with group A [risk ratio = 2.36, 95% confidence interval (95%CI): 0.58-9.58]; however, the difference did not reach statistical significance (Fisher’s exact test, P = 0.31), likely due to the limited sample size.

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Berger et al [ 43 ] similarly reported median OS of 23.6 months, with a nonsignificant trend toward better outcomes with HIPEC (29.7 months vs 19.5 months).

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The distribution of CRS and HIPEC procedures across three consecutive time periods is shown in Figure 1 , illustrating an increasing trend in the number of procedures performed over time.

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