Does standalone/combined subchondral bone marrow-derived mesenchymal stem/stromal cell injection offer significantly better clinical benefit to intraarticular injection in knee osteoarthritis?

After treatment, both groups showed significant improvements in pain and function, but the differences between the intra-articular only and subchondral + intra-articular groups did not reach statistical significance in patient-reported outcomes[ 20 ].

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The authors noted a trend toward better outcomes in the combined injection group (especially in patients with large BMLs) that likely failed to reach significance due to limited power.

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