The impact of adding mitomycin-C to radiotherapy plus oral tegafur-uracil on advanced-stage rectal cancer.

1 Although the aforementioned finding did not reach statistical significance, the authors found down-stage was associated with favorable DFS (OR, 2.2; 95% CI, 1.53-3.1) and OS rates (OR, 1.73; 95% CI, 1.23-2.43). 1 However, based on an increased low-grade AEs in MMC-CCRT group, the authors recommended that MMC-CCRT treatment should be used with caution in older patients and those with impaired bone marrow function.

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