Preclinical assessment of MAGE-A4-specific TCR-NK cells against solid tumors.

Interestingly, a small trend for higher degranulation of the CD3+ cells compared to the CD3− was also observed for the IrrTCR-NK, especially against A431_A2 cells.

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Interestingly, IFNγ and TNFα were detected at very low levels or almost immeasurable in the absence of TCR engagement, suggesting that the TCR can turn on cytokine release in the context of almost insignificant levels otherwise.

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Slightly increased levels of GM-CSF, GrzA, and CCL1 were also detected, although those did not reach statistical significance ( Fig. 3e ).

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