Emodin and physcion alleviate cholestatic liver injury by targeting FXR: hepatoprotective components identified in processed <i>Polygonum multiflorum</i> Thunb. using a comprehensive two-dimensional biochromatography system.

For FXR, a significant increase was observed in the UDCA and high-dose physcion groups, whereas the low-dose physcion group showed only an increasing trend without statistical significance ( P > 0.05).

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As shown in Figures 3D,E , the breakthrough curves of emodin and physcion at various concentrations demonstrated a clear trend: with decreasing concentrations, the breakthrough times increased.

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