Activation of endogenous PRKN by structural derepression is linked to increased turnover of the E3 ubiquitin ligase.

All four PRKN-activating mutations showed a trend toward greater p-S65-Ub levels in the absence of CCCP, and for two, PRKN A401D and PRKN W403A , this effect was statistically significant ( Figure 4B ).

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While neurons encoding for PRKN-activated mutations showed a slight trend toward more acidic to neutral mt-Keima compared to control cells already at baseline, this effect was not statistically significant ( Figure 4H ).

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