Barely Significant
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A novel <i>C. elegans</i> model for MAPT/Tau spreading reveals genes critical for endolysosomal integrity and seeded MAPT/Tau aggregation.

Autophagy · 2025 · PMC12758218 · PMID 40851193

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nearly significantno p-value reported
We tested the effects of SERINC4, which significantly reduced seeded MAPT/Tau aggregation, and the 10 genes that significantly enhanced seeded MAPT/Tau aggregation ( Figure 5E ), and 3 additional genes that were nearly significant in the hiPSC screen (SPHK2, SERINC1, HACD1).

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