In the multivariate Cox regression analysis of pathological variables T stage (HR 5.09, 95% CI 1.51–17.14, p – 0.009) and micro-vessel infiltration (HR 5.79, 95% CI 1.25–26.83, p – 0.025) remained significant independent prognostic factors for overall survival, while other parameters did not reach statistical significance ( Table 7 ).
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Overexpression of EMT-related transcription factors SNAI1 and ZEB1 is associated with more aggressive clinicopathological features of pancreatic cancer.
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