Can platelet to neutrophil ratio (PNR) serve as a viable alternative tool for monitoring sickle cell disease patients on hydroxyurea in low income countries?

When we compared haematological parameters between patients on HU and those not receiving the drug, we observed a lower total white blood cell (WBC) count among the HU group, although the difference did not reach statistical significance ( p = 0.1216).

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In addition to other parameters like number of painful crises, hospital admissions and blood transfusions are also used to monitor hydroxyurea intake since changes in Hb F levels may not be significant in some patients.

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