Reprogramming of the kynurenine pathway impairs NAD<sup>+</sup> homeostasis and mediates doxorubicin-induced cardiotoxicity in mice.

(2) increased flux toward NAD + synthesis, evidenced by elevated QA/Kyn (2.6-fold increase was observed, showing a clear visual trend that did not reach statistical significance) and QA/3-HAA (3.0-fold) ratios ( Fig. 6 M, N), and a 64 % reduction in the Kyn/Trp ratio ( Fig. 6 L).

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