A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy.

In a direct contradiction to the current dietary guidelines for patients in the weight loss clinic, low-protein-fed SG mice had 2-fold more weight loss, higher EE per gram of lean mass, a 6.5-fold higher expression of FGF21 , 16.4% reduction in weight recurrence, and a 40% reduction in fasting glucose, representing a highly significant metabolic benefit to low-protein diets.

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There was also a strong trend toward increased and a significantly elevated RER in WD SG and high-protein SG mice compared to their respective shams.

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