TDP-43-mediated alternative polyadenylation is associated with a reduction in VPS35 and VPS29 expression in frontotemporal dementia.

PLoS Biol · 2026 · PMC12768243 · PMID 41490046

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nominally significantno p-value reported

When examining associations of VPS35 APA with pTDP-43 levels, we noted a nominally significant positive association of VPS35 APA with pTDP-43 in unadjusted analysis ( S4 Fig and S5 Table ) but saw no difference in pTDP-43 levels between the High VPS35 and Low VPS35 APA groups ( S3 Fig ).

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