Male survival disadvantage in pulmonary hypertension: independent of aetiology, age, disease severity, comorbidities and treatment.

36 Notably, differences emerged when stratifying by age: in the REVEAL registry, sex differences were observed only in patients with PAH diagnosed at age ≤60 years, while adjusted Cox regression analysis did not reach statistical significance for the overall study population of 2059 patients with PAH. 36 In contrast, our analysis noted poorer survival rates of males across all three age groups (18–49, 50–64, >64 years) for both the overall PH group and PAH group.

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