Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice.

CNS Neurosci Ther · 2026 · PMC12771655 · PMID 41492821

Europe PMC DOI

hedged sentences

0.0524

closest p · 1.0× alpha

0.0524

boldest claim

The sentences

did not reach statistical significancep = 0.0524so close (0.05 < p ≤ 0.1)

Furthermore, although the increase in [HA] induced by pitolisant did not reach statistical significance ( p = 0.0524), there was a discernible upward trend in histamine levels. 3.6.

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a decreasing trendno p-value reported

At the same time, the PV and VTA showed a decreasing trend.

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an increasing trendno p-value reported

In contrast, there was an increasing trend in cFos‐IR cell numbers in the ventral tegmental area (VTA), nucleus accumbens (NAc), arcuate nucleus (Arc), periaqueductal gray (PAG), paraventricular nucleus (PV), and ventromedial hypothalamic nucleus (VMH) (all p < 0.05).

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