Organoids simulating the bovine oviduct mediate the embryo-maternal interface via extracellular vesicle-transmitted signaling.

Hum Reprod Open · 2026 · PMC12774516 · PMID 41503164

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a marked trendno p-value reported

Conversely and in competitive nature, a marked trend for the reduction of H3K27me3 persists with blastocysts derived from oEV supplementation (N-EVs and Ovi-EVs) aside from their origin ( in vitro vs in vivo ) compared to the controls under both HS and thermoneutral conditions (N-EVs: P = 0.0055 and P = 0.0005, respectively; Ovi-EVs: P = 0.1523 and P = 0.0245, respectively) ( Fig. 4C ).

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