Causal Relationships Between Major Depressive Disorder and Coronary Artery Disease Across Diverse Populations: A Bidirectional Mendelian Randomisation Study.

Trop Med Int Health · 2026 · PMC12775895 · PMID 41094686

Europe PMC DOI

hedged sentences

0.0400

closest p · 0.8× alpha

0.0400

boldest claim

The sentences

borderline significancep = 0.040actually significant

In the reverse direction, we identified a weak inverse association between CAD and MDD in EASs, with borderline significance ( p = 0.040) in the primary IVW analysis.

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reached borderline significanceno p-value reported

In EASs, while the inverse association between CAD and MDD reached borderline significance in the primary IVW analysis, neither MR‐Egger nor weighted median methods produced significant estimates, and confidence intervals were wide.

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