Metabolic and epigenetic abnormalities cause hepatic fibrogenesis in metabolic dysfunction-associated steatohepatitis model mice.

J Biol Chem · 2026 · PMC12775946 · PMID 41274506

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Consistent with the CDAHFD–MASH model, histone H3 methylation changes in GAN diet–fed ob/ob mice showed a trend toward increased H3K4me3, increased H3K9me3, and decreased H3K27me3 ( Fig. 9 B ).

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