The Impact of Vitamin C on Analgesic, Anti-inflammatory, and Hemostatic Outcomes After Total Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis.

Arch Bone Jt Surg · 2025 · PMC12777713 · PMID 41509597

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did not reach statistical significanceno p-value reported

49 The present meta-analysis demonstrates that vitamin C supplementation reduces IL-6 and C-reactive protein (CRP) levels within 24 hours after surgery; however, these differences compared with controls did not reach statistical significance, suggesting a biological effect that may not consistently translate into clinical benefit.

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