Multi-omics highlights the impacts of cryptorchidism history on immune microenvironment variation in TGCT.

Discov Oncol · 2025 · PMC12779800 · PMID 41339568

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IFI16 and PLEKHG6 showed a trend of progressively increasing expression from normal to pediatric UDT and TGCT, with IFI16 notably higher in TGCT-C + compared to TGCT-C − , suggesting its potential involvement in the progression from cryptorchidism to TGCT.

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