Does pharmacogenetic testing optimize antidepressant effectiveness in major depressive disorder? Data from a double-blind randomized controlled trial in a real-world clinical setting.

Eur Psychiatry · 2025 · PMC12780592 · PMID 41277612

Europe PMC DOI

hedged sentences

0.0530

closest p · 1.1× alpha

0.0530

boldest claim

The sentences

showed a trendp = 0.053so close (0.05 < p ≤ 0.1)

The two groups showed a trend toward differences ( F 1,132 = 3.82; p = 0.053), with significant differences observed at T4 ( p = 0.042) and T8 ( p = 0.013).

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a trend toward significanceno p-value reported

However, remission rates showed a trend toward significance, favoring TGTG (TGTG = 47.8% vs.

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