Consistently, A20-C3G-Y564H cells showed a trend toward reduced levels of the anti-apoptotic protein Bcl-xL compared to control cells (Fig. 3 G).
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C3G deregulation uncovers a dual role in B-cell lymphoma: tumor suppression and enhanced metastasis via Rap1 and Rac2 signaling.
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Notably, c-Raf protein levels also exhibited a decreasing trend in A20-C3G-Y564H cells (Fig. 4 C).