Genomic pathogenic alterations in the SWI/SNF complex compromise the outcomes of immunotherapy in Chinese patients with KRAS-mutant NSCLC by downregulating STING expression.

BMC Med · 2025 · PMC12781696 · PMID 41340120

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showed a trendno p-value reported

ARID(1A/1B/2)- mut patients showed a trend toward shorter OS than that observed for SWI/SNF-wt patients among 66 STK11 wt KEAP1 wt KRAS mut NSCLC patients (12.2 vs. 29.9 months, HR = 2.20 [95% CI 0.98–4.91], P = 0.052; Additional file 1: Fig.

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