Evolving Features of RASopathies Among Pregnancies With Abnormal Fetal Fluid Collections.

Prenat Diagn · 2026 · PMC12782120 · PMID 41360703

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did not reach statistical significanceno p-value reported

Although these did not reach statistical significance, a greater proportion of central nervous system anomalies (including ventriculomegaly and abnormal CSP) was observed among fetuses with PTPN11 variants associated with Noonan syndrome ( n = 20) (35% vs. 19%, p = 0.227), along with pleural effusions (80% vs. 54%, p = 0.065) and pelviectasis or hydronephrosis (45% vs. 23%, p = 0.116).

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