Reduced striatal dopamine transmission as a transdiagnostic substrate of psychomotor retardation.

99 , 100 In one study, patients with depression and PMR had lower CSF HVA concentrations than healthy controls and those with depression without PMR, but the numbers were small and did not reach statistical significance. 99 One study has found that HVA levels were positively correlated with psychomotor activity, but this included patients with depression and mania, so it is possible that the finding was driven by the latter group. 101 In catatonia, one study found increased HVA levels relative to healthy controls. 102 The same group found no relationship between an excited or retarded catatonia phenotype and HVA levels, although lorazepam responders appeared to have higher levels. 103 Before trying to interpret these findings, it is worth providing some caveats about the measurement of CSF HVA.

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