Targeting YAP-TEAD Interaction with Honokiol to Inhibit Melanoma Progression and Metastasis.

Biomol Ther (Seoul) · 2026 · PMC12782857 · PMID 41423957

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a clear trendno p-value reported

Within this focused honokiol analogue library, a clear trend emerged at the 4′-oxygen position: the 4′- O -n-butyl analogue HK03 showed stronger inhibition of the YAP-TEAD interaction than analogues bearing shorter alkyl chains or cycloalkyl substituents, suggesting that an appropriate balance of hydrophobic bulk and conformational flexibility at this site is beneficial for activity.

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