Enterohemorrhagic <i>Escherichia coli</i> targets Annexin A6 and ATG16L1 to inhibit autophagy and induce inflammation.

Additionally, Caco-2 cells with anxa6 knockout and transfected with pEGFP-EspF showed a trend toward increased LDH release compared to V2 cells transfected with pEGFP-EspF alone ( Figure 6E ), suggesting a potential additive effect of ANXA6 deficiency and EspF expression on cellular damage.

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