Risk Factors for Progression to Frequent Exacerbators in Stable Patients with Chronic Obstructive Pulmonary Disease.

Tuberc Respir Dis (Seoul) · 2026 · PMC12784124 · PMID 40921436

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0580

boldest claim

The sentences

did not reach statistical significancep>0.05actually significant

There was a tendency toward increased progression incidence among older patients, women, underweight patients (BMI <18.5 kg/m 2 ), those with GOLD group B, those with a high blood eosinophil count, and those with one moderate exacerbation; however, these trends did not reach statistical significance (p>0.05 for all). 3.

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a nonsignificant trendp=0.058so close (0.05 < p ≤ 0.1)

In stratified analysis, decreased percent-predicted post-bronchodilator FEV1 (aOR, 1.39; 95% CI, 1.05 to 1.85 per 10%pred decrease) and ICS-containg inhalers (aOR, 4.01; 95% CI, 1.61 to 9.95) predicted progression among patients with eosinophils <300/μL, while higher eosinophils ≥300/μL showed a nonsignificant trend (aOR, 1.16; 95% CI, 1.00 to 1.36; p=0.058).

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