Barely Significant
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GATA-<i>3</i> Suppression by DNAzyme Modulates Interleukin-10 and Liver Injury Markers in <i>db</i>/<i>db</i> Mice.

Biology (Basel) · 2025 · PMC12784981 · PMID 41514930

Europe PMCDOI
4
hedged sentences
0.0530
closest p · 1.1× alpha
0.0746
boldest claim

The sentences

borderline significantp = 0.053so close (0.05 < p ≤ 0.1)
On the other hand, treating db / db mice with hdg40 at 10 μg/mL led to a borderline significant ( p = 0.053) increase in the relative mRNA expression of Il10 in comparison to the control group ( Figure 6 e). 4.

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marginally significantp = 0.059so close (0.05 < p ≤ 0.1)
Additionally, hgd40 had no significant effect on the brown adipose tissue (BAT), as opposed to pioglitazone which resulted in a marginally significant ( p = 0.059) decrease in the BAT weight compared to the control ( Figure 3 c).

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borderline significancep = 0.0746so close (0.05 < p ≤ 0.1)
While none of the treatments had a marked effect on fatty changes in hepatocytes, 100 μg/mL of hgd40 increased the percentage of fatty cells in the liver with borderline significance ( Figure 5 a, p = 0.0746).

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did not reach statistical significanceno p-value reported
While a significant effect of hgd40 on IL-10 was observed with the low dose, the effect of the high dose did not reach statistical significance, but it followed a similar trend, especially in the serum.

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