The LXRβ/NF-κB axis reprograms CAR-T cells to resist exhaustion in the tumor microenvironment.

Oncoimmunology · 2026 · PMC12785237 · PMID 41496523

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did not reach statistical significanceno p-value reported

In a syngeneic B16F0-HER2 model, LXRβ OE RelB KO CAR-T cells exhibited the strongest overall tumor control, although the difference from LXRβ OE CAR-T cells did not reach statistical significance ( Figure 6b–e ).

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