Oral <i>Centella asiatica</i> Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice.

Int J Mol Sci · 2025 · PMC12785454 · PMID 41516082

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a decreasing trendno p-value reported

Ceramide levels also showed a decreasing trend following UVB exposure; although the overall ANOVA did not reach significance ( p > 0.05), pairwise analysis indicated a significant increase in the UV+CA80 group compared with UV+C ( p < 0.05), suggesting substantial biological variability at the protein level.

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did not reach statistical significanceno p-value reported

Tukey’s HSD analysis confirmed that the UV+CA80 group exhibited significantly higher Cers3 mRNA levels compared with the UV-irradiated control ( p < 0.01), whereas the increase observed in the UV+CA40 group did not reach statistical significance under conservative correction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.

Oral &lt;i&gt;Centella asiatica&lt;/i&gt; Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice.

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Oral <i>Centella asiatica</i> Extract Attenuates UVB-Induced Skin Photoaging via Antioxidant, Anti-Inflammatory, and Extracellular Matrix-Preserving Effects in Hairless Mice.