Therapeutic Plasma Exchange in COVID-19-Associated Sepsis: IL-6 Dynamics, Inflammatory Phenotypes, and Short-Term Organ-Failure Trajectories in a Real-World Cohort.

Baseline IL-6 showed a trend toward higher levels in the ≥3-session group (305.5 pg/mL, IQR 53.2–1306.3) than in the 1-session (143.1 pg/mL) or 2-session (37.0 pg/mL) groups ( p = 0.056), while baseline CRP and comorbidities such as diabetes, hypertension, obesity, and COPD were similarly distributed (all p > 0.28).

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