From Stress to Substance Use Disorders: The Expanding Role of Microglia-Astrocyte Crosstalk in Neuroimmune and Glutamate Alterations in the Nucleus Accumbens.

Int J Mol Sci · 2025 · PMC12787304 · PMID 41516262

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In patients with comorbid anxiety and depression, minocycline showed a trend toward reducing anxiety symptoms without significantly affecting depression scores in individuals primarily diagnosed with Major Depressive Disorder, with effects persisting post-treatment [ 450 ].

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