Impaired nitrogenous waste clearance promotes hepatocellular carcinoma.

When looking at the pyrimidine synthesis pathway, sgAss1 and sgArg1 mice showed marked increase of pyrimidine metabolites N -carbamoyl-aspartate, dihydroorotate, and orotate, while all four sgUCE groups showed a trend of increased uridine monophosphate, uridine, uracil, and CMP ( Fig. 5B ).

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