The Role of Omega-3 Polyunsaturated Fatty Acid Supplementation in Postoperative Recovery of Colorectal Cancer: Systematic Review and Meta-Analysis.

Nutrients · 2026 · PMC12787802 · PMID 41515289

Europe PMC DOI

hedged sentences

0.0200

closest p · 0.4× alpha

0.0200

boldest claim

The sentences

borderline significancep = 0.02actually significant

Heterogeneity analysis showed borderline significance ( I 2 = 49%; Q-test p = 0.02), indicating statistically significant heterogeneity among the studies.

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a strong trendno p-value reported

The pooled results demonstrated a strong trend toward reduced crypt cell proliferation in CRC patients receiving ω-3 PUFA supplementation, although this association did not reach conventional statistical significance [MD = −4.45, 95% CI (−9.06, 0.15), Z = 1.89, p = 0.06 > 0.05].

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