Salmon Nasal Cartilage Proteoglycan Ameliorate Joint Pain and Cartilage Degradation by Regulating Catabolic and Anabolic Homeostasis in MIA-Induced Osteoarthritis.

Although a numerical trend showing reduced IL-6 expression was observed across all three active treatment arms (CLX 20 mg/kg, SPG 50 mg/kg, SPG 100 mg/kg), these differences did not achieve statistical significance relative to the Control group.

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Although the SPG-treated groups exhibited a downward trend in MMP-2 expression, the difference did not reach statistical significance ( Figure 6 A, left upper panel).

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