Divergent molecular pathways drive monomorphic epitheliotropic and enteropathy-associated intestinal T-cell lymphoma.

Thus, considering the JAK-STAT pathway, there was a highly significant difference in mutation patterns in EATLs and MEITLs (p < 0.0001).

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Among T/NK signatures deconvoluted by gene expression, EATL tissues were enriched in T-cell CD4 naïve ( p < 0.001) or memory activated ( p < 0.001) and NK resting signatures ( p < 0.05), while MEITLs were enriched in T-cell CD4 memory resting ( p < 0.001) and NK activated signatures ( p < 0.001), and showed a trend for enrichment in T.cell.ɣδ and T.cell.CD8 signatures ( p = 0.08) (Fig. 5A ).

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With respect to disease subgroups, KRAS and TP53 were identified as drivers in atypical MEITL, JAK1 in EATL with CeD, and HLA-A was close to significance in EATL with no CeD history (q val = 0.019).

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