De-escalation of axillary surgery after neoadjuvant therapy in breast cancer: long-term outcomes of sentinel lymph node biopsy alone versus complete axillary lymph node dissection.

Ther Adv Med Oncol · 2026 · PMC12789383 · PMID 41523910

Europe PMC DOI

hedged sentences

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

did not reach statistical significancep = 0.059so close (0.05 < p ≤ 0.1)

By contrast, distant metastases tended to be less frequent in the SLNB-alone group (5.6% vs 8.5%), although this difference did not reach statistical significance ( p = 0.059).

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an increasing trendno p-value reported

A Dutch population-based study, involving 12,461 patients, revealed a substantial decrease in ALND and an increase in SLNB alone after NST in cN0 patients, alongside an increasing trend of ALND omission after NST in cN+ patients. 16 Our study also observed a considerable shift in axillary surgical management among patients undergoing NST in the past decades, characterized by a growing preference for SLNB alone and a decline in ALND utilization.

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