Nitrous oxide for the treatment of depression: a systematic review and meta-analysis.

50 , 54 Although the difference in dizziness or light headedness did not reach statistical significance (RR 0.68; 95% CI: 0.42–1.08; p = 0.10; I 2 = 0), and headache rates were similarly lower but non-significant (RR 0.39; 95% CI: 0.13–1.11; p = 0.08; I 2 = 0%), the risk of nausea and vomiting was significantly lower with 25% compared to 50% N2O (RR 0.42; 95% CI: 0.18–0.97; p = 0.04; I 2 = 35%). 50 , 54 These findings suggest that while both doses increase the risk of certain AEs relative to placebo, 25% N2O may offer a more favourable tolerability profile.

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