Intensive blood pressure control to prevent major cardiovascular events in individuals with high-normal blood pressure (prehypertension): PRINT-TAHA9 randomized clinical trial.

After adjusting for baseline variables, the only significant adverse event in the intervention group was syncope (aHR, 4.43; 95% CI, 1.06–18.44; P = 0.041), though this result was borderline significant.

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Due to our study’s limited sample size, we could not demonstrate a statistically significant preventive effect of pharmacotherapy on individual MACE components, though our analysis showed a trend toward benefit.

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