Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia.

In the jejunum (Figure 2 ), we observed significant increased levels of the NAE, N ‐stearoyl‐ethanolamine (SEA), and of oleic acid (OA) in FTD mice, while for 2‐OG and AA the increases showed only a statistical trend.

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This adaptive response did not reach statistical significance as it may have been possibly mitigated by the concomitant increased expression of the AEA‐degrading enzyme, FAAH.

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