Rapamycin Exerts Its Geroprotective Effects in the Ageing Human Immune System by Enhancing Resilience Against DNA Damage.

Simple linear regression analyses in circulating CD4 + T cells revealed a strong and highly significant positive correlation between p‐S6 and γH2AX levels in both treatment groups ( R 2 = 0.5481 [placebo], 0.7758 [rapamycin], p < 0.0001 in both groups), indicating that mTOR activity and DNA damage are positively linked in vivo (Figure 6b,c ).

also in 132,142 other papers

While a larger Phase 3 trial did not reach significance for reduction in mild RTIs, there was a clear trend to improved immune function (Mannick et al. 2021 ). mTOR inhibitors therefore offer a therapeutic route to enhance ageing immune responses against viral pathogens for which we currently lack effective pharmacological interventions.

also in 19,460 other papers